COMPLEMENT INHIBITOR CSMD1 MODULATES EPIDERMAL GROWTH FACTOR RECEPTOR ONCOGENIC SIGNALING AND SENSITIZES BREAST CANCER CELLS TO CHEMOTHERAPY

Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy

Abstract Background Human CUB and Sushi multiple domains 1 (CSMD1) is a large membrane-bound tumor suppressor in custom congratulations banner breast cancer.The current study aimed to elucidate the molecular mechanism underlying the effect of CSMD1 in highly invasive triple negative breast cancer (TNBC).Methods We examined the antitumor action of C

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Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1.

Prokineticins are angiogenic hormones that activate two G protein-coupled receptors: PKR1 and PKR2.PKR1 has emerged as a critical mediator of cardiovascular homeostasis and cardioprotection.Identification of non-peptide PKR1 agonists that contribute to myocardial repair and collateral vessel growth hold promises for treatment of heart diseases.Thro

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Legendary LD: Learning Disabilities, Creativity, and Social Class

In this paper I draw on several data sources to make the case that the attribution of superior creative resources and knowall.blog related alternative and/or enhanced cognitive styles to Learning disabilities (LD) was embedded within the original conception of LD tenga flip orb and continues to be propagated by many in the LD community.I conclude b

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